Reproduction Abstracts

Kisspeptin neuropeptides stimulate release of GnRH to maintain mammalian fertility. Kisspeptins are encoded by the Kiss1 gene and directly stimulate GnRH neurons via the G-protein coupled receptor54 (GPR54). Transgenic mice with inactivating mutations of Kiss1 or Gpr54 are sterile and have underdeveloped gonads (hypogonadism) and low GnRH levels caused by a failure to secrete GnRH. The aim of this study was to determine whether the sterility of mutan...